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Targeted Allele Detail
Symbol: Traf6tm1.1Mpa
Name: TNF receptor-associated factor 6; targeted mutation 1.1, Manolis Pasparakis
MGI ID: MGI:3836555
Synonyms: TRAF6flox
Gene: Traf6  Location: Chr2:101678429-101701669 bp, + strand  Genetic Position: Chr2, 53.9 cM
Germline Transmission:  Earliest citation of germline transmission: J:145306
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neomycin resistance cassette. (J:202191)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Traf6 Mutation:  6 strains or lines available
Original:  J:145306 Imai Y, et al., Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell. 2008 Apr 18;133(2):235-49
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory