Tg(Scgb1a1-Map2k1*S218V*S222V)1Eli
Transgene Detail

Summary

• Symbol: Tg(Scgb1a1-Map2k1*S218V*S222V)1Eli
• Name: transgene insertion 1, Jack A Elias
• MGI ID: MGI:3836054
• Synonyms: CC10-dnMEK1 Tg
• Transgene: Tg(Scgb1a1-Map2k1*S218V*S222V)1Eli Location: unknown
• Alliance: Tg(Scgb1a1-Map2k1*S218V*S222V)1Eli page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Scgb1a1-Map2k1*S218V*S222V)1Eli expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Map2k1 (MGI:1346866)	Transgene codes for a protein with two serine to valine mutations.

• Mutation details: A rat CC10 promoter drives lung-specific expression of a Map2k1 sequence in which serines 218 and 222 had been mutated to valines (dnMEK1). A human growth hormone polyadenylation sequence is added at the 3' end of the construct.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:105338 Lee PJ, et al., ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. J Clin Invest. 2006 Jan;116(1):163-73
• All: 2 reference(s)