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Tmpotm1.1Foi
Targeted Allele Detail
Nomenclature
Symbol: Tmpotm1.1Foi
Name: thymopoietin; targeted mutation 1.1, Roland Foisner
MGI ID: MGI:3835992
Synonyms: Lap2alpha-
Gene: Tmpo  Location: Chr10:91147571-91181315 bp, - strand  Genetic Position: Chr10, 45.66 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:145628
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAt least six alternative transcripts can be derived from this gene locus. This mutation targeted exon 4, which is necessary for generation of a protein product that localizes to the nucleoplasm. A loxP site and a FRT-flanked neomycin cassette was placed upstream of exon 4 and an additional loxP site was placed downstream of the exon. Founder mice were crossed with Cre-deleter mice to remove exon 4 and the neomycin cassette. Homozygote mice lacked the nucleoplasm specific protein isoform but expressed the other protein isoforms as determined by immunoblot analysis of heart and intestinal extracts. (J:145628)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tmpo Mutation:  29 strains or lines available
References
Original:  J:145628 Naetar N, et al., Loss of nucleoplasmic LAP2alpha-lamin A complexes causes erythroid and epidermal progenitor hyperproliferation. Nat Cell Biol. 2008 Nov;10(11):1341-8
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory