Plekho1^tm1Fhe
Targeted Allele Detail

Summary

• Symbol: Plekho1^tm1Fhe
• Name: pleckstrin homology domain containing, family O member 1; targeted mutation 1, Fuchu He
• MGI ID: MGI:3835921
• Synonyms: CKIP-1^-
• Gene: Plekho1 Location: Chr3:95896110-95903258 bp, - strand Genetic Position: Chr3, 41.65 cM, cytoband F2
• Alliance: Plekho1^tm1Fhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145650
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis of mouse embryonic fibroblasts. (J:145650)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plekho1 Mutation: 16 strains or lines available

References

• Original: J:145650 Lu K, et al., Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1. Nat Cell Biol. 2008 Aug;10(8):994-1002
• All: 11 reference(s)