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Targeted Allele Detail
Symbol: Rad18tm1Stat
Name: RAD18 E3 ubiquitin protein ligase; targeted mutation 1, Satoshi Tateishi
MGI ID: MGI:3835812
Gene: Rad18  Location: Chr6:112619850-112696686 bp, - strand  Genetic Position: Chr6, 52.42 cM, cytoband F
Germline Transmission:  Earliest citation of germline transmission: J:145534
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA floxed IRES-beta-geo cassette with a polyadenylation sequence was inserted into the exon encoding amino acids Thr-90 through Lys-201. Transient cre expression was used to remove the IRES-beta-geo cassette. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblasts. (J:81138, J:145534)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rad18 Mutation:  22 strains or lines available
Original:  J:145534 Sun J, et al., Rad18 is required for long-term maintenance of spermatogenesis in mouse testes. Mech Dev. 2009 Mar-Apr;126(3-4):173-83
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory