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Targeted Allele Detail
Symbol: Npas4tm1Ooe
Name: neuronal PAS domain protein 4; targeted mutation 1, Norihisa Ooe
MGI ID: MGI:3835590
Synonyms: NXF-
Gene: Npas4  Location: Chr19:5034383-5040344 bp, - strand  Genetic Position: Chr19, 4.2 cM
Brain damage in Npas4tm1Ooe/Npas4tm1Ooe mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:145569
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1, 2, and 3 were replaced with a neo cassette. The absence of transcript expression was confirmed by real-time PCR on brain tissues. (J:145569)
Generation of the Npas4tm1Ooe allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npas4 Mutation:  20 strains or lines available
Original:  J:145569 Ooe N, et al., Functional characterization of basic helix-loop-helix-PAS type transcription factor NXF in vivo: putative involvement in an 'on demand' neuroprotection system. J Biol Chem. 2009 Jan 9;284(2):1057-63
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
The Jackson Laboratory