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Npas4tm1Ooe
Targeted Allele Detail
Nomenclature
Symbol: Npas4tm1Ooe
Name: neuronal PAS domain protein 4; targeted mutation 1, Norihisa Ooe
MGI ID: MGI:3835590
Synonyms: NXF-
Gene: Npas4  Location: Chr19:5034383-5040344 bp, - strand  Genetic Position: Chr19, 4.2 cM
Brain damage in Npas4tm1Ooe/Npas4tm1Ooe mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:145569
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1, 2, and 3 were replaced with a neo cassette. The absence of transcript expression was confirmed by real-time PCR on brain tissues. (J:145569)
Generation of the Npas4tm1Ooe allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Npas4 Mutation:  20 strains or lines available
References
Original:  J:145569 Ooe N, et al., Functional characterization of basic helix-loop-helix-PAS type transcription factor NXF in vivo: putative involvement in an 'on demand' neuroprotection system. J Biol Chem. 2009 Jan 9;284(2):1057-63
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory