About   Help   FAQ
Ptpn5tm1Pjlo
Targeted Allele Detail
Nomenclature
Symbol: Ptpn5tm1Pjlo
Name: protein tyrosine phosphatase, non-receptor type 5; targeted mutation 1, Paul J Lombroso
MGI ID: MGI:3835526
Synonyms: STEP-
Gene: Ptpn5  Location: Chr7:46727543-46783432 bp, - strand  Genetic Position: Chr7, 30.7 cM, cytoband B3-B5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:145584
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details1284 bp of genomic sequence encoding the catalytic site was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:145584)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptpn5 Mutation:  23 strains or lines available
References
Original:  J:145584 Venkitaramani DV, et al., Knockout of STriatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylation. Synapse. 2009 Jan;63(1):69-81
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/30/2021
MGI 6.17
The Jackson Laboratory