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Targeted Allele Detail
Symbol: Ptpn5tm1Pjlo
Name: protein tyrosine phosphatase, non-receptor type 5; targeted mutation 1, Paul J Lombroso
MGI ID: MGI:3835526
Synonyms: STEP-
Gene: Ptpn5  Location: Chr7:46727543-46783432 bp, - strand  Genetic Position: Chr7, 30.7 cM, cytoband B3-B5
Germline Transmission:  Earliest citation of germline transmission: J:145584
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation details1284 bp of genomic sequence encoding the catalytic site was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:145584)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptpn5 Mutation:  23 strains or lines available
Original:  J:145584 Venkitaramani DV, et al., Knockout of STriatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylation. Synapse. 2009 Jan;63(1):69-81
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory