Gjd2^tm4Kwi
Targeted Allele Detail

Summary

• Symbol: Gjd2^tm4Kwi
• Name: gap junction protein, delta 2; targeted mutation 4, Klaus Willecke
• MGI ID: MGI:3835284
• Synonyms: Cx36flox(CFP)
• Gene: Gjd2 Location: Chr2:113840082-113844100 bp, - strand Genetic Position: Chr2, 57.54 cM, cytoband F3
• Alliance: Gjd2^tm4Kwi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145292
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in the 5' UTR and a DNA segment containing sequences for an FRT flanked neomycin resistance gene, another loxP site, and a cyan fluorescent protein gene was inserted in the 3' UTR. (J:145292, J:174834)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gjd2 Mutation: 23 strains or lines available

References

• Original: J:145292 Van Der Giessen RS, et al., Role of olivary electrical coupling in cerebellar motor learning. Neuron. 2008 May 22;58(4):599-612
• All: 6 reference(s)