Tg(LPA,LPAL2,PLG)1Hgc
Transgene Detail

Summary

• Symbol: Tg(LPA,LPAL2,PLG)1Hgc
• Name: transgene insertion 1, Human Genome Center
• MGI ID: MGI:3835029
• Synonyms: apo(a) YAC, Tg(LPA LPAL-2 PLG)1Hgc
• Transgene: Tg(LPA,LPAL2,PLG)1Hgc Location: unknown
• Alliance: Tg(LPA,LPAL2,PLG)1Hgc page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(LPA,LPAL2,PLG)1Hgc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PLG (5340)

  Plg	(MGI:97620)

• Mutation details: Transgenic mice were created using a 270 kb YAC (CEPH clone 366H2) bearing a genomic DNA segment from human Chromosome 6 containing the lipoprotein, Lp(a)-like 2 gene; a 110 kb variant of the gene encoding lipoprotein, Lp(a); and the plasminogen gene. The LPA allele was determined to have 12 tandem copies of the variable copy number, 5.5 kb kringle IV-like repeat. Transgenic mice were shown by northern blot and RT-PCR analysis to express LPA mRNA in the liver and by immunoblot analysis to have significant (up to 75 mg/dL) plasma LPA; expression is suppressed by normal adult male levels of testosterone. (J:144538)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

LPA [lipoprotein, Lp(a)] was formerly unofficially called Apo(a), apolipoprotein (a); this is not to be confused with the APOA series, apolipoproteins A1, A2, A4 and A5. LPAL2 (lipoprotein, Lp(a)-like 2) was previously designated officially APOAL, apolipoprotein(a)-like. Both are recent evolutionary developments that notably are present in primates but not in rodents.

References

• Original: J:144538 Frazer KA, et al., The apolipoprotein(a) gene is regulated by sex hormones and acute-phase inducers in YAC transgenic mice. Nat Genet. 1995 Apr;9(4):424-31
• All: 5 reference(s)