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Symbol: |
TcraLn3Jae |
Name: |
T cell receptor alpha chain; recombination line 3, Rudolf Jaenisch |
MGI ID: |
MGI:3834626 |
Synonyms: |
LN3alpha |
Gene: |
Tcra Location: Chr14:52665424-54461655 bp, + strand Genetic Position: Chr14, cytoband D1-D2
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Strain of Origin: |
(129S4/SvJae x C57BL/6)F1
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Allele Type: |
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Not Applicable |
Mutation: |
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Other
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Mutation details: This allele was created by transfer of a male alpha-beta T cell nucleus into an enucleated oocyte. A blastocyte was grown and from this an ES cell clone was derived. The two Tcra alleles in this ES cell were recombined with one allele having a productive, in frame recombination and the other a non-productive, out of frame recombination. Only the productive allele containing a Valpha3.1-J30 recombination was propagated and is the one described here. Recombination was determined by Southern blotting and inverted PCR.
(J:143006)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tcra Mutation: |
98 strains or lines available
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Original: |
J:143006 Serwold T, et al., Early TCR expression and aberrant T cell development in mice with endogenous prerearranged T cell receptor genes. J Immunol. 2007 Jul 15;179(2):928-38 |
All: |
3 reference(s) |
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