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Hbb-ytm2.1Fier
Targeted Allele Detail
Nomenclature
Symbol: Hbb-ytm2.1Fier
Name: hemoglobin Y, beta-like embryonic chain; targeted mutation 2.1, Steven Fiering
MGI ID: MGI:3834619
Synonyms: deltaEy
Gene: Hbb-y  Location: Chr7:103851745-103853240 bp, - strand  Genetic Position: Chr7, 54.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:145362
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details1.1 kb of DNA containing the promoter region, exon1, and exon2 was replaced with a floxed PGK-hygro selection cassette in ES cells already containing the targeted allele Hbb-bh1 allele. The selection cassettes in the two genes were subsequently excised by breeding mice to CMV-cre transgenic mice. This allele is only found in conjunction with Hbb-bh1. (J:145362)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hbb-y Mutation:  1 strain or line available
References
Original:  J:145362 Hu X, et al., Transcriptional interference among the murine beta-like globin genes. Blood. 2007 Mar 1;109(5):2210-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory