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Targeted Allele Detail
Symbol: Slitrk1tm1Jaru
Name: SLIT and NTRK-like family, member 1; targeted mutation 1, Jun Aruga
MGI ID: MGI:3834477
Gene: Slitrk1  Location: Chr14:108909988-108914239 bp, - strand  Genetic Position: Chr14, 56.78 cM, cytoband E3
Germline Transmission:  Earliest citation of germline transmission: J:145441
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to delete 2.5 kb of the exon containing entire open-reading frame. A floxed neo replaced the sequence and was subsequently excised by crossing with mice expressing Cre in the germ line. Western blot of mutant brain samples showed no bands corresponding to Slitrk1 protein. (J:145441)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slitrk1 Mutation:  23 strains or lines available
Original:  J:145441 Katayama K, et al., Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities. Mol Psychiatry. 2010 Feb;15(2):177-84
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory