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Mep1atm1Bond
Targeted Allele Detail
Nomenclature
Symbol: Mep1atm1Bond
Name: meprin 1 alpha; targeted mutation 1, Judith S Bond
MGI ID: MGI:3833886
Gene: Mep1a  Location: Chr17:43474324-43502812 bp, - strand  Genetic Position: Chr17, 19.73 cM, cytoband C1-D1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:145147
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette with an in-frame stop codon was inserted into the zinc-catalytic center encoded by exon 7. In the process, 140 bp were deleted at the targeting site. End-point PCR of kidney mRNA demonstrated the absence of transcription. Absence of protein product was indicated by immunoblot analysis of urine. (J:145147)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mep1a Mutation:  24 strains or lines available
References
Original:  J:145147 Banerjee S, Meprin Metalloproteases Modulate Intestinal Host Response. Biochem Mol Biol. 2008;
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory