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Tg(Thy1-SERPINI1*G392E)333Icka
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-SERPINI1*G392E)333Icka
Name: transgene insertion 333, Ichiro Kato
MGI ID: MGI:3833390
Synonyms: G392E-Tg
Transgene: Tg(Thy1-SERPINI1*G392E)333Icka  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL x DBA)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-SERPINI1*G392E)333Icka expresses 1 gene
 
Mutation detailsThe promoter was used to drive neuron-specific expression of the human cDNA containing nucleotide substitutions that result in the amino acid substitution of glutamic acid for glycine at position 392 (G392E). This mutation was originally discovered in patients with familial encephalopathy with neuroserpin inclusion bodies (FENIB). Three lines were created (333, 42, 115) with line 333 expressing at much higher levels than lines 42 and 115. (J:144649)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:144649 Takasawa A, et al., Mutation-, aging-, and gene dosage-dependent accumulation of neuroserpin (G392E) in endoplasmic reticula and lysosomes of neurons in transgenic mice. J Biol Chem. 2008 Dec 19;283(51):35606-13
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory