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Transgene Detail
Symbol: Tg(Thy1-SERPINI1*G392E)333Icka
Name: transgene insertion 333, Ichiro Kato
MGI ID: MGI:3833390
Synonyms: G392E-Tg
Transgene: Tg(Thy1-SERPINI1*G392E)333Icka  Location: unknown  
Strain of Origin:  (C57BL x DBA)F1
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Thy1-SERPINI1*G392E)333Icka expresses 1 gene
Mutation detailsThe promoter was used to drive neuron-specific expression of the human cDNA containing nucleotide substitutions that result in the amino acid substitution of glutamic acid for glycine at position 392 (G392E). This mutation was originally discovered in patients with familial encephalopathy with neuroserpin inclusion bodies (FENIB). Three lines were created (333, 42, 115) with line 333 expressing at much higher levels than lines 42 and 115. (J:144649)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:144649 Takasawa A, et al., Mutation-, aging-, and gene dosage-dependent accumulation of neuroserpin (G392E) in endoplasmic reticula and lysosomes of neurons in transgenic mice. J Biol Chem. 2008 Dec 19;283(51):35606-13
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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