Tg(GH1-cre)1Sac
Transgene Detail
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Symbol: |
Tg(GH1-cre)1Sac |
Name: |
transgene insertion 1, Sally A Camper |
MGI ID: |
MGI:3833232 |
Synonyms: |
Tg(Gh-cre)SAC1 |
Transgene: |
Tg(GH1-cre)1Sac Location: unknown
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Alliance: |
Tg(GH1-cre)1Sac page
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Strain of Origin: |
(C57BL/6J x SJL/J)F2
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Transgene Type: |
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Transgenic (Recombinase) |
Mutation: |
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Insertion
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Tg(GH1-cre)1Sac expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Homolog in Mouse |
Note |
human |
GH1 (2688) |
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Mutation details: The human growth hormone locus control region (-16.2 to -14.6 kb relative to the GH1 promoter) was fused to 1.77 kb of rat Gh1 promoter to drive expression of a cre recombinase cassette in the pituitary gland. About 30-50 copies of the transgene construct inserted into the genome after injection into zygotes. When crossed with cre-reporter strains, cre expression was observed in the pituitary somatotropes, with limited expression in lactotropes, and no detectable expression in other pituitary cell types. Cre expression was also detected in the skin of embryonic forelimbs and trunk, and in adult testis, ovary, and kidney.
(J:144723)
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Structure of the Tg(GH1-cre)1Sac transgene |
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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GH1
(human)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:144723 Nasonkin IO, et al., Cre-mediated recombination in pituitary somatotropes. Genesis. 2009 Jan;47(1):55-60 |
All: |
1 reference(s) |
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