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QTL Variant Detail
QTL variant: Mssq2KK/TaJcl
Name: mandible size and shape QTL 2; KK/TaJcl
MGI ID: MGI:3832866
QTL: Mssq2  Location: unknown  Genetic Position: Chr2, Syntenic
Strain of Specimen:  KK.Cg-Ay/TaJcl
Allele Type:    QTL
Mutation:    Undefined
    Heterozygosity for C57BL/6JJcl and KK/TaJcl alleles at Mssq2 confer increased mandible size. (J:143893)
View phenotypes for all genotypes (concatenated display).
Mssq2 was identified in a subgroup of (C57BL/6JJcl x KK-Ay/TaJcl)F2 animals carrying the Ay allele.

Mapping and Phenotype information for this QTL, its variants and associated markers


Genetic loci affecting mandible size and shape were mapped using 190 mice from a (C57BL/6JJcl x KK-Ay/TaJcl)F2 intercross. Of the F2 population, 97 animals had the Ay/a genotype and 93 animals had the a/a genotype. Thirteen measurements taken from the right mandible and 3 principal components were assessed in experimental animals 6-7 months of age. Parental strain KK-Ay/TaJcl displays increased values across most of the 13 mandible measurements compared to parental strain C57BL/6JJcl. The Ay allele increases mandible size in KK animals compared to the a allele. A panel of 100 polymorphic markers was used for linkage analysis.

Mssq2 (mandible size and shape QTL 2) mapped to 38.3 cM on mouse Chromosome 2 near D2Mit182 (LOD=4.4) in the Ay/a F2 group. This locus is linked to one mandible measurement with the heterozygous genotype at Mssq2 conferring increased mandible size. Manln2 (27.3 cM) is a previously identified QTL located near Mssq2. Acvr2a at 30 cM is a possible candidate gene for Mssq2.

Original:  J:143893 Suto J, Identification of multiple quantitative trait loci affecting the size and shape of the mandible in mice. Mamm Genome. 2009 Jan;20(1):1-13
All:  1 reference(s)

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