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Tg(Ela2a-Prss1*,GFP)1Dbs
Transgene Detail
Nomenclature
Symbol: Tg(Ela2a-Prss1*,GFP)1Dbs
Name: transgene insertion 1, Dafna Bar-Sagi
MGI ID: MGI:3832840
Synonyms: R122H_mPRSS1
Transgene: Tg(Ela2a-Prss1*,GFP)1Dbs  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ela2a-Prss1*,GFP)1Dbs expresses 1 gene
 
Mutation detailsThe rat promoter was used to drive acinar cell-specific expression of a flag-tagged cDNA with nucleotide substitutions that result in the amino acid substitution of histidine for arginine at position 122 (R122H) and an IRES-GFP reporter. Three lines were made with copy numbers of the transgene ranging from ten (in two of three lines) to low numbers (in one line). No line numbers were given. (J:144663)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:144663 Archer H, et al., A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen. Gastroenterology. 2006 Dec;131(6):1844-55
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory