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Pomgnt1tm1Stk
Targeted Allele Detail
Nomenclature
Symbol: Pomgnt1tm1Stk
Name: protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase; targeted mutation 1, Shin'ichi Takeda
MGI ID: MGI:3832592
Synonyms: POMGnT1-deficient
Gene: Pomgnt1  Location: Chr4:116150498-116159844 bp, + strand  Genetic Position: Chr4, 53.1 cM, cytoband C7
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:144928
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 18 was replaced with a neo cassette. The absence of protein activity was confirmed by enzymatic assay and the lack of the glycosylated alpha-dystroglycan super moiety in western blot analysis. (J:144928)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pomgnt1 Mutation:  22 strains or lines available
References
Original:  J:144928 Miyagoe-Suzuki Y, et al., Reduced proliferative activity of primary POMGnT1-null myoblasts in vitro. Mech Dev. 2009 Mar-Apr;126(3-4):107-16
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory