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Targeted Allele Detail
Symbol: Slc6a1tm1Mlit
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 1; targeted mutation 1, Jian Fei
MGI ID: MGI:3832387
Synonyms: GAT1-, Slc6a1tm1Fei, Slc6a1tm1Nfms
Gene: Slc6a1  Location: Chr6:114282635-114317532 bp, + strand  Genetic Position: Chr6, 53.05 cM, cytoband E3
Germline Transmission:  Earliest citation of germline transmission: J:144919
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2 and 3 were replaced with a neomycin cassette. Immunoblot analysis of brain extracts demonstrated that heterozygotes had one-third the expression of protein of wild-types and that homozygotes had no expression of the protein. (J:144919)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc6a1 Mutation:  32 strains or lines available
Original:  J:144919 Cai YQ, et al., Mice with genetically altered GABA transporter subtype I (GAT1) expression show altered behavioral responses to ethanol. J Neurosci Res. 2006 Aug 1;84(2):255-67
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory