About   Help   FAQ
Spry1tm2Jdli
Targeted Allele Detail
Nomenclature
Symbol: Spry1tm2Jdli
Name: sprouty RTK signaling antagonist 1; targeted mutation 2, Jonathan D Licht
MGI ID: MGI:3832050
Synonyms: Sprouty1lacZ, SprylacZ
Gene: Spry1  Location: Chr3:37639947-37644598 bp, + strand  Genetic Position: Chr3, 18.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:144775
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES0lacZ and a floxed Neomycin selection cassette replaced the 3' half of exon 3 including part of the open reading frame. Mice with this modified allele were crossed with beta-actin cre deleter mice to excise neomycin. (J:144775)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Spry1 Mutation:  9 strains or lines available
References
Original:  J:144775 Thum T, et al., MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature. 2008 Dec 18;456(7224):980-4
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/11/2020
MGI 6.14
The Jackson Laboratory