About   Help   FAQ
Targeted Allele Detail
Symbol: Spry1tm2Jdli
Name: sprouty RTK signaling antagonist 1; targeted mutation 2, Jonathan D Licht
MGI ID: MGI:3832050
Synonyms: Sprouty1lacZ, SprylacZ
Gene: Spry1  Location: Chr3:37639947-37644598 bp, + strand  Genetic Position: Chr3, 18.46 cM
Germline Transmission:  Earliest citation of germline transmission: J:144775
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn IRES0lacZ and a floxed Neomycin selection cassette replaced the 3' half of exon 3 including part of the open reading frame. Mice with this modified allele were crossed with beta-actin cre deleter mice to excise neomycin. (J:144775)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Spry1 Mutation:  9 strains or lines available
Original:  J:144775 Thum T, et al., MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature. 2008 Dec 18;456(7224):980-4
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory