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Hdac3tm1.1Eno
Targeted Allele Detail
Nomenclature
Symbol: Hdac3tm1.1Eno
Name: histone deacetylase 3; targeted mutation 1.1, Eric N Olson
MGI ID: MGI:3831693
Synonyms: Hdac3loxP
Gene: Hdac3  Location: Chr18:37936971-37955015 bp, - strand  Genetic Position: Chr18, 19.81 cM, cytoband B3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:144604
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted in intron 10 and an frt flanked neomycin selection as well as a second loxP site were placed in intron 14. The neomycin cassette was subsequently removed by crossing to FLPe transgenic mice which leaves exons 11-14 flanked by loxP. (J:144604)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hdac3 Mutation:  8 strains or lines available
References
Original:  J:144604 Montgomery RL, et al., Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice. J Clin Invest. 2008 Nov;118(11):3588-97
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory