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Targeted Allele Detail
Symbol: Fgfr3tm1.1Aomw
Name: fibroblast growth factor receptor 3; targeted mutation 1.1, Andrew O M Wilkie
MGI ID: MGI:3831364
Synonyms: Fgfr3P244R
Gene: Fgfr3  Location: Chr5:33721724-33737067 bp, + strand  Genetic Position: Chr5, 17.83 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:144356
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted
Mutation:    Insertion
Mutation detailsA point mutation changing a C to G at position 731 in exon 7 and a floxed neo cassette in intron 7 were introduced by homologous recombination. The neo cassette was then removed by Cre mediated recombination. (J:144356)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Fgfr3 Mutation:  8 strains or lines available
Original:  J:144356 Twigg SR, et al., Skeletal analysis of the Fgfr3(P244R) mouse, a genetic model for the Muenke craniosynostosis syndrome. Dev Dyn. 2009 Feb;238(2):331-42
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory