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Fgfr3tm1.1Aomw
Targeted Allele Detail
Nomenclature
Symbol: Fgfr3tm1.1Aomw
Name: fibroblast growth factor receptor 3; targeted mutation 1.1, Andrew O M Wilkie
MGI ID: MGI:3831364
Synonyms: Fgfr3P244R
Gene: Fgfr3  Location: Chr5:33721674-33737067 bp, + strand  Genetic Position: Chr5, 17.83 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:144356
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsA point mutation changing a C to G at position 731 in exon 7 (P244R) and a floxed neo cassette in intron 7 were introduced by homologous recombination. The neo cassette was then removed by Cre mediated recombination. (J:144356)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 19 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Fgfr3 Mutation:  29 strains or lines available
References
Original:  J:144356 Twigg SR, et al., Skeletal analysis of the Fgfr3(P244R) mouse, a genetic model for the Muenke craniosynostosis syndrome. Dev Dyn. 2009 Feb;238(2):331-42
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory