About   Help   FAQ
Tg(Prnp-ATN1)150Dbo
Transgene Detail
Nomenclature
Symbol: Tg(Prnp-ATN1)150Dbo
Name: transgene insertion 150, David R Borchelt
MGI ID: MGI:3831358
Synonyms: AT-FL-65Q-150
Transgene: Tg(Prnp-ATN1)150Dbo  Location: unknown  
Transgene
origin
Strain of Origin:  (C3H x C57BL/6J)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details
Inheritance:    Dominant
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Six independent transgenic mouse lines were generated (low expression: 79, 82, 150; high expression: 124, 125, 165) as determined by Northern blot analysis (J:70362). All lines exhibit a similar phenotype, however, high expressing lines develop symptoms beginning at 1-2 months. Low expressing lines develop symptoms at 8-12 months.

References
Original:  J:70362 Schilling G, et al., Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA. Neuron. 1999 Sep;24(1):275-86
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory