About   Help   FAQ
Transgene Detail
Symbol: Tg(Prnp-ATN1)150Dbo
Name: transgene insertion 150, David R Borchelt
MGI ID: MGI:3831358
Synonyms: AT-FL-65Q-150
Transgene: Tg(Prnp-ATN1)150Dbo  Location: unknown  
Strain of Origin:  (C3H x C57BL/6J)F2
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Prnp-ATN1)150Dbo expresses 1 gene
Mutation detailsThe transgene comprises a cDNA encoding full length human atrophin 1 containing a 65 residue polyglutamine tract, encoded by 65 CAG repeats, inserted into an expression cassette containing the promoter, 5' intronic and 5' and 3' untranslated region sequences of the mouse prion protein gene. This transgenic line carries more than ten copies of the construct and, as shown by northern and western blot analysis, expresses human atrophin 1 mRNA and protein in the brain. (J:70362)
Inheritance:    Dominant
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Six independent transgenic mouse lines were generated (low expression: 79, 82, 150; high expression: 124, 125, 165) as determined by Northern blot analysis (J:70362). All lines exhibit a similar phenotype, however, high expressing lines develop symptoms beginning at 1-2 months. Low expressing lines develop symptoms at 8-12 months.

Original:  J:70362 Schilling G, et al., Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA. Neuron. 1999 Sep;24(1):275-86
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.03
The Jackson Laboratory