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Tg(Prnp-ATN1)124Dbo
Transgene Detail
Nomenclature
Symbol: Tg(Prnp-ATN1)124Dbo
Name: transgene insertion 124, David R Borchelt
MGI ID: MGI:3831350
Synonyms: AT-FL-65Q-124
Transgene: Tg(Prnp-ATN1)124Dbo  Location: unknown  
Transgene
origin
Strain of Origin:  (C3H x C57BL/6J)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details
Inheritance:    Dominant
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Six independent transgenic mouse lines were generated (low expression: 79, 82, 150; high expression: 124, 125, 165) as determined by Northern blot analysis (J:70362). All lines exhibit a similar phenotype, however, high expressing lines develop symptoms beginning at 1-2 months. Low expressing lines develop symptoms at 8-12 months.

References
Original:  J:70362 Schilling G, et al., Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA. Neuron. 1999 Sep;24(1):275-86
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory