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Bag3tm1.1Jhl
Targeted Allele Detail
Nomenclature
Symbol: Bag3tm1.1Jhl
Name: BCL2-associated athanogene 3; targeted mutation 1.1, Jeong-Hwa Lee
MGI ID: MGI:3831334
Synonyms: Bis-
Gene: Bag3  Location: Chr7:128523583-128546977 bp, + strand  Genetic Position: Chr7, 70.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:144416
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsMale mice carrying the Bag3tm1Jhl allele, which has exon 4 of the gene locus flanked by loxP sites, were bred with cre transgenic mice to excise exon 4 from the germline. Gene inactivation was confirmed in tail and liver extracts by failure to detect protein in immunoblot assays using three different antibodies raised against whole, COOH-terminal, and NH2-terminal peptides. (J:144416)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bag3 Mutation:  8 strains or lines available
References
Original:  J:144416 Youn DY, et al., Bis deficiency results in early lethality with metabolic deterioration and involution of spleen and thymus. Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1349-57
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory