Bag3^tm1Jhl
Targeted Allele Detail

Summary

• Symbol: Bag3^tm1Jhl
• Name: BCL2-associated athanogene 3; targeted mutation 1, Jeong-Hwa Lee
• MGI ID: MGI:3831333
• Synonyms: Bis^flox
• Gene: Bag3 Location: Chr7:128125340-128148705 bp, + strand Genetic Position: Chr7, 70.26 cM
• Alliance: Bag3^tm1Jhl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144416
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted in the EcoRV site upstream from exon 4 and a loxP-flanked neomycin cassette was inserted downstream of exon 4. Correct targeting was confirmed by Southern blotting. (J:144416)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bag3 Mutation: 31 strains or lines available

References

• Original: J:144416 Youn DY, et al., Bis deficiency results in early lethality with metabolic deterioration and involution of spleen and thymus. Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1349-57
• All: 3 reference(s)