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Targeted Allele Detail
Symbol: Nbntm3Jpt
Name: nibrin; targeted mutation 3, John H J Petrini
MGI ID: MGI:3831174
Synonyms: NbndeltaBC
Gene: Nbn  Location: Chr4:15957925-15992589 bp, + strand  Genetic Position: Chr4, 6.66 cM, cytoband A
Germline Transmission:  Earliest citation of germline transmission: J:144172
Parent Cell Line:  AC1 (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe targeting vector used to create Nbntm1Jpt was used in embryonic stem cells containing Nbntm2.1Jpt to create an allele that coded for amino acids 221 to 727. The predicted protein lacks the FHA, BRCT and ATM-interacting domains. (J:144172)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nbn Mutation:  38 strains or lines available
Original:  J:144172 Shull ER, et al., Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS. Genes Dev. 2009 Jan 15;23(2):171-80
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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