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Tg(Pbsn-IGF1*)5305Ng
Transgene Detail
Nomenclature
Symbol: Tg(Pbsn-IGF1*)5305Ng
Name: transgene insertion 5305, Norman M Greenberg
MGI ID: MGI:3831172
Synonyms: IGF-1des, PB-Des, PB Des IGF-1, PB-IGF1des1,3
Transgene: Tg(Pbsn-IGF1*)5305Ng  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Pbsn-IGF1*)5305Ng expresses 1 gene
 
Mutation detailsA transgenic construct containing the human insulin-like growth factor 1 (somatomedin C) isoform, IGF-1des (that has a 3-amino acid deletion in the N terminus of the mature protein), under the control of the minimal -426/+28 rat probasin promoter, and carrying SV40 polyadenylation site sequences was injected into fertilized FVB/N mouse eggs. Three lines were generated (5299, 5305, and 6206). Founder line 5305 showed the highest expression and was characterized most thoroughly. (J:144539)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:144539 Kaplan-Lefko PJ, et al., Enforced epithelial expression of IGF-1 causes hyperplastic prostate growth while negative selection is requisite for spontaneous metastogenesis. Oncogene. 2008 May 1;27(20):2868-76
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory