Tg(Il17f-cre)1Awai
Transgene Detail

Summary

• Symbol: Tg(Il17f-cre)1Awai
• Name: transgene insertion 1, Ari Waisman
• MGI ID: MGI:3831089
• Synonyms: IL-17F-Cre
• Transgene: Tg(Il17f-cre)1Awai Location: unknown
• Alliance: Tg(Il17f-cre)1Awai page

Transgene origin

• Strain of Origin: C57BL/6 x DBA

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Il17f-cre)1Awai expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Il17f

• Mutation details: A bacterial artificial chromosome containing the Il17f locus was used to construct a transgene vector. Exons 1 and 2 of the locus were replaced with a cre recombinase expression cassette and a neomycin selection cassette. Founder mice were obtained after injection of linearized vector into the pronuclei of fertilized eggs. When transgenic mice were crossed to mice carrying the cre-reporter allele Gt(ROSA)26Sor^tm1(EYFP)Cos, cre expression was detected in CD8⁺ T cells and, to a lesser extent, CD4⁺ T cells after culturing in vitro under Th17-polarizing conditions. Cre expression was also detected in vivo by CD4⁺ T cells after induction of experimental autoimmune encephalomyelitis. (J:144336)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Il17f (species not specified) Summary of all recombinase alleles driven by Il17f.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:144336 Croxford AL, et al., Cutting edge: An IL-17F-CreEYFP reporter mouse allows fate mapping of Th17 cells. J Immunol. 2009 Feb 1;182(3):1237-41
• All: 5 reference(s)