Ptpn3^{Gt(RRR573)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Ptpn3^{Gt(RRR573)Byg}
• Name: protein tyrosine phosphatase, non-receptor type 3; gene trap RRR573, BayGenomics
• MGI ID: MGI:3830861
• Synonyms: Ptpn3 deltaPTP, Ptpn3^GtRRR573PdK
• Gene: Ptpn3 Location: Chr4:57190841-57301837 bp, - strand Genetic Position: Chr4, 31.66 cM
• Alliance: Ptpn3^{Gt(RRR573)Byg} page

Mutation origin

• Mutant Cell Line: RRR573
• Germline Transmission: Earliest citation of germline transmission: J:144280
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf
• Mutation details: A betageo gene trap vector inserted into exon 27 of the locus where the nucleophilic cysteine residue necessary for enzymatic activity is encoded. No protein (endogenous or n-terminal portion of endogenous protein fused to betageo) was detected by immunoblot assays on homozygote brain extract. (J:144280)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRR573	CG784680 ; (MGI Seq Detail)	5' RACE	Chr4:57197507-57205029 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  126 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn3 Mutation: 173 strains or lines available

References

• Original: J:144280 Bauler TJ, et al., Normal TCR signal transduction in mice that lack catalytically active PTPN3 protein tyrosine phosphatase. J Immunol. 2007 Mar 15;178(6):3680-7
• All: 2 reference(s)