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Tg(Neurod2-Smo*A1)199Jols
Transgene Detail
Nomenclature
Symbol: Tg(Neurod2-Smo*A1)199Jols
Name: transgene insertion 199, James M Olson
MGI ID: MGI:3830738
Synonyms: ND2:SmoA1, SmoA1, SmoA1:199
Transgene: Tg(Neurod2-Smo*A1)199Jols  Location: unknown  Genetic Position: Chr14, cytoband C1
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Constitutively active, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Neurod2-Smo*A1)199Jols expresses 1 gene
 
Mutation detailsThe ND2:SmoA1 transgene contains the entire mouse smoothened homolog (Drosophila) Smo gene, with the constitutively active point mutation SmoA1 (W539L), driven by the 1kb mouse neurogenic differentiation 2 (Neurod2) promoter. Several lines were generated (lines 199, 193, 234, 255 and 201) with varying levels of expression (30-, 45-, 36-, 2- and 3-fold, respectively, relative to wild0type expression). (J:93861)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:93861 Hallahan AR, et al., The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas. Cancer Res. 2004 Nov 1;64(21):7794-800
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory