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Targeted Allele Detail
Symbol: Itga4tm1Mshi
Name: integrin alpha 4; targeted mutation 1, Motomu Shimaoka
MGI ID: MGI:3830623
Synonyms: Itga4-R/AGFFKR
Gene: Itga4  Location: Chr2:79085770-79163467 bp, + strand  Genetic Position: Chr2, 47.38 cM
Germline Transmission:  Earliest citation of germline transmission: J:144092
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsExon 28 was replaced with one in which nucleotide substitutions resulted in amino acid substitution of GFFKA for GFFKR. This sequence is involved in the formation of a membrane-proximal salt bridge necessary for inactivation. A self-excising neo cassette was inserted upstream of exon 28 and subsequently deleted in chimeras. (J:144092)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itga4 Mutation:  42 strains or lines available
Original:  J:144092 Imai Y, et al., Genetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates alpha(4) integrins. Blood. 2008 Dec 15;112(13):5007-15
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory