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Drd1tm1Tono
Targeted Allele Detail
Nomenclature
Symbol: Drd1tm1Tono
Name: dopamine receptor D1; targeted mutation 1, Taketoshi Ono
MGI ID: MGI:3829942
Synonyms: D1R-
Gene: Drd1  Location: Chr13:54051186-54055658 bp, - strand  Genetic Position: Chr13, 28.4 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:143054
Parent Cell Line:  E14TG2aIV (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe open reading frame was replaced with an xanthine-guanine phosphoribosyl transferase gene and neo cassette. The absence of protein expression was confirmed by western blot analysis on adult brain extracts. (J:143054)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 12 strains available      Cell Lines: 0 lines available
Carrying any Drd1 Mutation:  35 strains or lines available
References
Original:  J:143054 Tran AH, et al., Dopamine D1 receptor modulates hippocampal representation plasticity to spatial novelty. J Neurosci. 2008 Dec 10;28(50):13390-400
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory