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Slc39a13tm1Thir
Targeted Allele Detail
Nomenclature
Symbol: Slc39a13tm1Thir
Name: solute carrier family 39 (metal ion transporter), member 13; targeted mutation 1, Toshio Hirano
MGI ID: MGI:3829756
Synonyms: ZIP13 KO
Gene: Slc39a13  Location: Chr2:90892136-90900762 bp, - strand  Genetic Position: Chr2, 50.44 cM, cytoband E1
Growth retardation, kyphosis, osteopenia, and abnormal cartilage development in Slc39a13tm1Thir/Slc39a13tm1Thir mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:143911
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 6 through 8 were replaced with a neomycin resistance cassette. The deleted sequence encodes the HEX-PHEXGD motif. (J:143911)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 19 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc39a13 Mutation:  15 strains or lines available
References
Original:  J:143911 Fukada T, et al., The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways. PLoS One. 2008;3(11):e3642
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory