Tg(KRT14-Gdnf)097Kma
Transgene Detail

Summary

• Symbol: Tg(KRT14-Gdnf)097Kma
• Name: transgene insertion 097, Katheryn M Albers
• MGI ID: MGI:3829499
• Synonyms: GDNF-OE
• Transgene: Tg(KRT14-Gdnf)097Kma Location: unknown
• Alliance: Tg(KRT14-Gdnf)097Kma page

Transgene origin

• Strain of Origin: (C3H x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT14-Gdnf)097Kma expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Gdnf (MGI:107430)

• Mutation details: The K14-GDNF transgene contains 2.3 kb of the human K14 keratin promoter sequence, the mouse GDNF cDNA and intron-exon splice sites from the human growth hormone gene. ELISAs were done to measure peptide levels in the skin, DRG, spinal cord, and plasma of adult GDNF-OE and wild-type mice. A sixfold increase of GDNF protein was detected in transgenic skin, whereas in DRG a 4.23-fold increase was measured. Spinal cord levels were also increased by 2.67-fold, suggesting anterograde transport of GDNF from the DRG to the dorsal horn. GDNF was not detected in the plasma of either wild-type or transgenic animals. (J:76684)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:76684 Zwick M, et al., Glial cell line-derived neurotrophic factor is a survival factor for isolectin B4-positive, but not vanilloid receptor 1-positive, neurons in the mouse. J Neurosci. 2002 May 15;22(10):4057-65
• All: 5 reference(s)