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Cc2d1atm1Zjc
Targeted Allele Detail
Nomenclature
Symbol: Cc2d1atm1Zjc
Name: coiled-coil and C2 domain containing 1A; targeted mutation 1, Zhijian Chen
MGI ID: MGI:3829256
Synonyms: 1AKO-A, Mit5-
Gene: Cc2d1a  Location: Chr8:84132828-84147936 bp, - strand  Genetic Position: Chr8, 40.32 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177407
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA targeting vector containing a beta galactosidase gene (lacZ), followed by a loxP-flanked neomycin resistance cassette was fused in-frame to exon 1. The tergeting vector deleted exons 1-10 (amino acids 3-349) of the gene. Southern and Western blot failed to detect DNA or protein, respectively, in mutants. (J:177407)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cc2d1a Mutation:  20 strains or lines available
References
Original:  J:177407 Zhao M, et al., Cc2d1a, a C2 domain containing protein linked to nonsyndromic mental retardation, controls functional maturation of central synapses. J Neurophysiol. 2011 Apr;105(4):1506-15
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory