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Plp1tm1Frca
Targeted Allele Detail
Nomenclature
Symbol: Plp1tm1Frca
Name: proteolipid protein (myelin) 1; targeted mutation 1 Franca Cambi
MGI ID: MGI:3828298
Synonyms: PLP-ISEdel
Gene: Plp1  Location: ChrX:136822166-136838582 bp, + strand  Genetic Position: ChrX, 59.1 cM, cytoband F1-F2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:143305
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted
Mutation:    Intragenic deletion
 
Mutation detailsUsing a 'hit and run' strategy 19 bp in intron 3 were deleted. This region is critical for the production of the Plp1 isoform, and its deletion results in decreased transcript expression of the Plp1 isofom relative to the DM20 isoform as confirmed by RT-PCR on brain extracts. (J:143305)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plp1 Mutation:  17 strains or lines available
References
Original:  J:143305 Wang E, et al., Deletion of a splicing enhancer disrupts PLP1/DM20 ratio and myelin stability. Exp Neurol. 2008 Dec;214(2):322-30
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory