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Transgene Detail
Symbol: Tg(Dspp-TGFB1)3Kul
Name: transgene insertion 3, Ashok B Kulkarni
MGI ID: MGI:3828146
Synonyms: dTGF-beta1, Tg(TGFB1)3Kul
Transgene: Tg(Dspp-TGFB1)3Kul  Location: unknown  
Gross tooth abnormalities in Tg(Dspp-TGFB1)3Kul/? mice

Show the 3 phenotype image(s) involving this allele.

Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Constitutively active, Inserted expressed sequence)
Mutation:    Insertion
Tg(Dspp-TGFB1)3Kul expresses 1 gene
Mutation detailsThe transgene comprises 6 kilobases of mouse genomic DNA containing the upstream regulatory elements of the dentin sialophosphoprotein (Dspp) gene, including the noncoding first exon and the first intron, followed by a 1.5 kb cDNA encoding a constitutively active porcine transforming growth factor beta 1, in which Cys223 and Cys225 have been replaced by serine, and an SV40 polyadenylation signal. Transgenic mouse lines with independent transgene integration sites were produced from 5 transgenic founder animals. This record represents the line of mice with a high level of transgene expression. TGFB1 is expressed from this transgene predominantly in the odontoblasts. (J:118918)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:118918 Thyagarajan T, et al., Reduced expression of dentin sialophosphoprotein is associated with dysplastic dentin in mice overexpressing transforming growth factor-beta 1 in teeth. J Biol Chem. 2001 Apr 6;276(14):11016-20
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
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