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Targeted Allele Detail
Symbol: Dusp6tm1Jmol
Name: dual specificity phosphatase 6; targeted mutation 1, Jeffery D Molkentin
MGI ID: MGI:3827011
Gene: Dusp6  Location: Chr10:99099093-99103351 bp, + strand  Genetic Position: Chr10, 51.13 cM, cytoband C3
Increased satellite cell numbers in Dusp6tm1Jmol/Dusp6tm1Jmol regenerating muscle following injury

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:142966
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAll 3 exons were replaced with a neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein in the lung, spleen, thymus, and heart of homozygous mice. (J:142966)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dusp6 Mutation:  19 strains or lines available
Original:  J:142966 Maillet M, et al., DUSP6 (MKP3) null mice show enhanced ERK1/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility. J Biol Chem. 2008 Nov 7;283(45):31246-55
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory