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Tg(Tcra,Tcrb)9Rest
Transgene Detail
Nomenclature
Symbol: Tg(Tcra,Tcrb)9Rest
Name: transgene insertion 9, Nicholas P Restifo
MGI ID: MGI:3826818
Synonyms: TRP-1 TCR
Transgene: Tg(Tcra,Tcrb)9Rest  Location: unknown  Genetic Position: ChrY, Syntenic
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Tcra,Tcrb)9Rest expresses 2 genes
 
Mutation detailsThe TRP-1 TCR was generated from immunized Tyrp1B-w mice. Clone 7A6 expressed Valpha3.2Vbeta14 TCR chains. These TCR sequences were cloned into separate vectors and co-injected into microinjected into C57BL/6 fertilized eggs. Founder line 9 was subsequently established and the transgene insertion site was found on the Y chromosome. (J:138466)
Phenotypes
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:138466 Muranski P, et al., Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood. 2008 Jul 15;112(2):362-73
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory