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Targeted Allele Detail
Symbol: Cftrtm1.1Cwr
Name: cystic fibrosis transmembrane conductance regulator; targeted mutation 1.1, Case Western Reserve University
MGI ID: MGI:3822761
Synonyms: Cftrdelta10
Gene: Cftr  Location: Chr6:18170687-18322768 bp, + strand  Genetic Position: Chr6, 8.1 cM, cytoband A3
Germline Transmission:  Earliest citation of germline transmission: J:142723
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsGerm line, cre mediated recombination was used to remove exon 10. Absence of full-length transcript expression was confirmed by RT-PCR on lung and intestine extracts. Expression of a smaller than normal transcript is observed. (J:142723)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cftr Mutation:  47 strains or lines available
Original:  J:142723 Hodges CA, et al., Generation of a conditional null allele for Cftr in mice. Genesis. 2008 Oct;46(10):546-52
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory