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Bcamtm1Jhm
Targeted Allele Detail
Nomenclature
Symbol: Bcamtm1Jhm
Name: basal cell adhesion molecule; targeted mutation 1, Jeffrey H Miner
MGI ID: MGI:3822736
Gene: Bcam  Location: Chr7:19756131-19771016 bp, - strand  Genetic Position: Chr7, 9.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:142595
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA 2 kb fragment containing exons 11 though 13 was deleted resulting in the absence of 142 amino acids of the fifth Ig domain, the transmembrane domain, and the first 20 amino acids of the cytoplasmic tail. Splicing from exon 10 to 14 results in an out of frame transcript. The absence of protein exppression was confirmed by immunohistochemistry on neuromuscular junctions. (J:142595)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcam Mutation:  17 strains or lines available
References
Original:  J:142595 Nishimune H, et al., Laminins promote postsynaptic maturation by an autocrine mechanism at the neuromuscular junction. J Cell Biol. 2008 Sep 22;182(6):1201-15
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory