Sirt3^tm1Cxd
Targeted Allele Detail

Summary

• Symbol: Sirt3^tm1Cxd
• Name: sirtuin 3; targeted mutation 1, Chu-Xia Deng
• MGI ID: MGI:3822535
• Synonyms: SIRT3^neo
• Gene: Sirt3 Location: Chr7:140443579-140462222 bp, - strand Genetic Position: Chr7, 86.07 cM, cytoband F4
• Alliance: Sirt3^tm1Cxd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142586
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 4. (J:142586)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sirt3 Mutation: 30 strains or lines available

References

• Original: J:142586 Ahn BH, et al., A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14447-52
• All: 1 reference(s)