Smad3^tm1Zuk
Targeted Allele Detail

Summary

• Symbol: Smad3^tm1Zuk
• Name: SMAD family member 3; targeted mutation 1, Martin M Matzuk
• MGI ID: MGI:3822465
• Synonyms: Smad3^flox
• Gene: Smad3 Location: Chr9:63554049-63665276 bp, - strand Genetic Position: Chr9, 34.22 cM, cytoband D
• Alliance: Smad3^tm1Zuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142827
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 2 and 3 were flanked by loxP sites and an frt-flanked neo cassette was inserted upstream of exon 2. Following recombination, a functional protein may be expressed. (J:142827)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad3 Mutation: 18 strains or lines available

References

• Original: J:142827 Li Q, et al., Redundant roles of SMAD2 and SMAD3 in ovarian granulosa cells in vivo. Mol Cell Biol. 2008 Dec;28(23):7001-11
• All: 19 reference(s)