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Tg(RNU6-RNAi:Cldn16)551Dago
Transgene Detail
Nomenclature
Symbol: Tg(RNU6-RNAi:Cldn16)551Dago
Name: transgene insertion 551, Daniel A Goodenough
MGI ID: MGI:3822350
Synonyms: pUG-U6-551, Tg(UBC-RNAi:Cldn16)551Dago
Transgene: Tg(RNU6-RNAi:Cldn16)551Dago  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe human promoter was used to drive ubiquitous expression of GFP and a short hairpin RNA targeting Cldn16. Three lines were created (lines 453, 551 and 756) with line 756 exhibiting no knockdown effect with the other two lines down regulating transcript expression by greater than 100-fold as determined by real time quantitative RT-PCR. (J:122766)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:122766 Hou J, et al., Transgenic RNAi depletion of claudin-16 and the renal handling of magnesium. J Biol Chem. 2007 Jun 8;282(23):17114-22
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory