Stxbp2^tm1Adch
Targeted Allele Detail

Summary

• Symbol: Stxbp2^tm1Adch
• Name: syntaxin binding protein 2; targeted mutation 1, Roberto Adachi
• MGI ID: MGI:3822180
• Synonyms: Stxp2^fl
• Gene: Stxbp2 Location: Chr8:3680955-3693644 bp, + strand Genetic Position: Chr8, 1.92 cM, cytoband A1
• Alliance: Stxbp2^tm1Adch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:280238
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 1 is flanked by loxP sites and an frt-flanked PGK-neomycin selection cassette was inserted downstream of exon 1. The PGK-neomycin selection cassette was removed via FLP-mediated recombination in the germline. (J:280238)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stxbp2 Mutation: 36 strains or lines available

References

• Original: J:280238 Jaramillo AM, et al., Different Munc18 proteins mediate baseline and stimulated airway mucin secretion. JCI Insight. 2019 Mar 21;4(6)
• All: 2 reference(s)