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Crybb2tm1Itl
Targeted Allele Detail
Nomenclature
Symbol: Crybb2tm1Itl
Name: crystallin, beta B2; targeted mutation 1, inGenious Targetin Laboratory
MGI ID: MGI:3821715
Synonyms: Crybb2tm1Igl
Gene: Crybb2  Location: Chr5:113058258-113070117 bp, - strand  Genetic Position: Chr5, 55.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:142278
Parent Cell Line:  iTL IC1 (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on lens extracts. (J:142278)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crybb2 Mutation:  2 strains or lines available
References
Original:  J:142278 Zhang J, et al., Targeted knockout of the mouse betaB2-crystallin gene (Crybb2) induces age-related cataract. Invest Ophthalmol Vis Sci. 2008 Dec;49(12):5476-83
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory