Zbtb7b^tm1Litt
Targeted Allele Detail

Summary

• Symbol: Zbtb7b^tm1Litt
• Name: zinc finger and BTB domain containing 7B; targeted mutation 1, Dan R Littman
• MGI ID: MGI:3821617
• Synonyms: ThPOK^FN
• Gene: Zbtb7b Location: Chr3:89284953-89300976 bp, - strand Genetic Position: Chr3, 39.09 cM, cytoband A1-A2
• Alliance: Zbtb7b^tm1Litt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141144
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding sequence of this gene locus is contained within exons 2 and 3. A loxP-flanked neomycin resistance cassette was placed upstream of exon 2 and an additional loxP site was placed downstream of exon 3. The presence of the neomycin resistance cassette created a hypomorph allele where protein expression was reduced by 80% in CD4⁺ T cells from mice compound heterozygote for this allele and a null allele. (J:141144)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbtb7b Mutation: 24 strains or lines available

References

• Original: J:141144 Egawa T, et al., ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat Immunol. 2008 Oct;9(10):1131-9
• All: 1 reference(s)