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Zbtb7btm1Litt
Targeted Allele Detail
Nomenclature
Symbol: Zbtb7btm1Litt
Name: zinc finger and BTB domain containing 7B; targeted mutation 1, Dan R Littman
MGI ID: MGI:3821617
Synonyms: ThPOKFN
Gene: Zbtb7b  Location: Chr3:89377644-89394776 bp, - strand  Genetic Position: Chr3, 39.09 cM, cytoband A1-A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:141144
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  B6(Cg)-Tyrc-2J/J
Mutation
description
Allele Type:    Targeted (Conditional ready, Hypomorph)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe coding sequence of this gene locus is contained within exons 2 and 3. A loxP-flanked neomycin resistance cassette was placed upstream of exon 2 and an additional loxP site was placed downstream of exon 3. The presence of the neomycin resistance cassette created a hypomorph allele where protein expression was reduced by 80% in CD4+ T cells from mice compound heterozygote for this allele and a null allele. (J:141144)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zbtb7b Mutation:  14 strains or lines available
References
Original:  J:141144 Egawa T, et al., ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Nat Immunol. 2008 Oct;9(10):1131-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory